Not be using tricyclic antidepressants or lithium, SSRIs, haloperidol, or MAOIs (some of these increase psychedelic effects, some of them reduce effects).
Not be using 5-HTP, St John’s Wort or any other supplements that “may affect serotonergic function”
Do not consume cannabis or dronabinol for at least 24 h before a session.
Not be using Ritonavir/Indinavir
Tricyclic antidepressants include:
Taking psyilocybin while on an MAOI can dramatically increase the effects of the experience.
MAOIs are most commonly found in the prescription anti-depressants:
Aurorex or Manerix (moclobemide).
Check with your doctor if you are not sure whether your prescription medication is an MAOI.
SSRIs are not reported to cause a dangerous interaction, though they are reported to substantially decrease the effects of psilocybin.
Research recommends against using cannabis or marijuana with psilocybin.
There are some other medications which may interfere with psilocybin:
anti-convulsants or anti-epileptic medications such as
Neurontin(gabapentin) and Topamax(topiramate). The exact mechanism by
which topiramate works, for example, is still unknown, so it is
impossible to even guess whether or not it will interfere with
medications which are either synthetic analogs of certain
hormones or which regulate hormone production: Prednisone and
Synthroid, for example. There is no direct evidence to suggest that
these drugs will interact with psilocybin, but hormones have a very
complex and inter-related effect on numerous body systems. We have
seen a few reports suggesting that thyroid levels play a part in
* tranquilizers and mood-altering medications such as Xanax,
Valium, Prozac and Wellbutrin.
Ondansetron (Zofran) and Compazine(prochlorperazine)
Imitrex (and associated triptans):
In relation to migraine headaches based upon many reports, triptans are one of the most likely
medications to block the clusterbusting effects of psychedelics. In our opinion, they should be avoided both before, during and after,
beginning psychedelic treatments for cluster headaches.
sumatriptan (Imitrex®, Imigran®) injections
sumatriptan (Imitrex®, Imigran®) tablets
zolmitriptan (Zomig®) tablets
sumatriptan (Imitrex®, Imigran®) nasal spray
naratriptan (Amerge®, Naramig®) tablets
rizatriptan (Maxalt®) tablets and rizatriptan orally dissolvable
zolmitriptan orally dissolvable (Zomig-ZMT®) tablets
almotriptan (Axert®) tablets
frovatriptan (Frova®) tablets
eletriptan (Relpax®) tablets